Denzel Washington
Role: Dr. Jerome Davenport
Derek Luke
Role: Antwone Fisher
Malcolm David Kelley
Role: Antwone Fisher Age 7
Cory Hodges
Role: Antwone Fisher Age 14
Joy Bryant
Role: Cheryl Smolley
Salli Richardson-Whitfield
Role: Berta Davenport
Leonard Earl Howze
Role: Pork Chop
Kente Scott
Role: Kansas City
Rainoldo Gooding
Role: Grayson
Novella Nelson
Role: Mrs. Tate
Stephen Snedden
Role: Berkley
Sung Kang
Role: Receptionist
James Brolin
Role: The Captain (uncredited)
Jenifer Lewis
Role: Aunt Mary Williams (uncredited)
Charles Robinson
Role: Howard
Earl Billings
Role: Uncle James
Vernee Watson-Johnson
Role: Aunt Annette
De'Angelo Wilson
Role: Jesse
Kim Johnson
Role: Disc Jockey
Leo Nepomuceno
Role: SP #1
Cordell Stokes
Role: Keith - Age 5
Ellis Williams
Role: Reverand Tate (as Ellis E. Williams)
Timothy Reddick
Role: Dwight - Age 8
Jascha Washington
Role: Jesse - Age 8
Margaret Ford-Taylor
Role: Eda
Jada S. Louie
Role: Jeannette
Brandon Biggins
Role: Eddie
Eddie Baccus
Role: Blind Piano Player
David Fowler
Role: Chief Master-At-Arms
Sean'e La'Dae
Role: Edward
Linda Cevallos
Role: Sexy Woman
O.L. Duke
Role: Uncle Duke
Michelle Davison
Role: Johnny Mae
Ruth Stehle
Role: Snide Clerk
John Pittman
Role: Another Clerk
Edward C. Reynolds III
Role: Man
Rita Pearson
Role: Cashier
Janaya Reynolds
Role: Young Girl #1
Na'tasha Marie Evans
Role: Young Girl #2
Lynn E. Charles
Role: Spinoza's Wife
Mary Bradley Marable
Role: Older Lady
Teresa Hoefke
Role: Case Worker
Angela Gillespie-Winborn
Role: Woman in White
Regina Daye Allen
Role: Woman in Dream Sequence (uncredited)
Gary A. Jones
Role: Relative (uncredited)
Tierney Deanne Collins
Role: Young Girl (uncredited)
Eliza Cortez
Role: County Clerk Worker (uncredited)
Ruby Gonzalez
Role: Salsa Dancer (uncredited)