Adrien Brody
Role: Leonard Chess
Jeffrey Wright
Role: Muddy Waters
Gabrielle Union
Role: Geneva Wade
Columbus Short
Role: Little Walter
Cedric the Entertainer
Role: Willie Dixon
Emmanuelle Chriqui
Role: Revetta Chess
Eamonn Walker
Role: Howlin' Wolf
Tammy Blanchard
Role: Isabelle Allen
Eric Bogosian
Role: Alan Freed
Norman Reedus
Role: Chess Engineer
Yasiin Bey
Role: Chuck Berry
Josh Alscher
Role: Mick Jagger
Tim Bellow
Role: Man in the Caddy
Marc Bonan
Role: Keith Richards
Douglas Crosby
Role: Policeman (Little Walter beating)
Dexter Darden
Role: Geneva's Teenage Son
Veronika Dash
Role: Blonde Girl
Sean Shyboy Davis
Role: Toothless Hillbilly Little Walter
Eshaya Draper
Role: Charles Waters
Christopher Durham
Role: Policeman (with Chuck Berry)
Shiloh Fernandez
Role: Phil Chess
Jill Flint
Role: Shelly Feder
Erik Frandsen
Role: Engineer - Present Day
Gano Grills
Role: Slick Pimp
Suzette Gunn
Role: Minnie Ripperton
Jordan Haynes
Role: Pot Strong
William Hill
Role: Policeman (with the Stones)
Mike Hodge
Role: Bartender
Tyler Humphrey
Role: Muddy - Age 6
Kevin Jackson
Role: Mysterious Black Man
Albert Jones
Role: Hubert Sumlin
Rayan Lawrence
Role: Harmonica Player
Chyna Layne
Role: Pot's Girlfriend Juanita
Kevin Mambo
Role: Jimmy Rogers
Rebecca Pappa
Role: Another Blonde
Jonathan Earl Peck
Role: Man Who Rolled 7
Q-Tip
Role: Hip Hop Artist
Ginnie Randall
Role: Muddy's Grandmother
Ashlee Ray
Role: Muddy's Floozy #1
Jake Robards
Role: Producer - Present Day
Jay O. Sanders
Role: Mr. Feder
Samuel Smith
Role: Guitarist
Valence Thomas
Role: James Cotton
Carmen Ziina Vasquez
Role: Muddy's Floozy #2
Isiah Whitlock, Jr.
Role: Mississippi DJ
Kade Alexie
Role: Guitar Player (uncredited)
Kandé Amadou
Role: Little Walter's Girlfriend (uncredited)
Angelina Aucello
Role: Teenybopper (uncredited)
Lawrence P. Beron
Role: Overseer (uncredited)
Ryan Curtis
Role: Picnic Boyfriend (uncredited)
Vincent D'Onofrio
Role: Mississippi DJ (uncredited)
Seth Donavan
Role: Chuck Berry Concertgoer (uncredited)
John Farrer
Role: Etta's Violinist (uncredited)
Doug W. Goldman
Role: Etta's Trumpet Player (uncredited)
Evan Hart
Role: Young Lover (uncredited)
Tiffany M. Johnson
Role: Girlfriend (uncredited)
Vianca Johnson
Role: Field Worker (uncredited)
Andrew Kaempfer
Role: Chicago Cop (uncredited)
Tony Lawson
Role: Vendor (uncredited)
Rege Lewis
Role: Bystander (uncredited)
Malikha Mallette
Role: Little Walter's Girlfriend (uncredited)
Cerrone May
Role: Muddy's Band Member (uncredited)
Adaku Ononogbo
Role: Muddy Waters' Girlfriend (uncredited)
Catherine Pierce
Role: Shocked Bystander (uncredited)
Stephen Seidel
Role: Officer Brown (uncredited)
Derrick Simmons
Role: Dice Player (uncredited)
