Ben Stiller
Role: Larry Daley
Amy Adams
Role: Amelia Earhart
Owen Wilson
Role: Jedediah Smith
Hank Azaria
Role: Kahmunrah / The Thinker / Abe Lincoln
Robin Williams
Role: Theodore Roosevelt
Christopher Guest
Role: Ivan the Terrible
Alain Chabat
Role: Napoleon Bonaparte
Steve Coogan
Role: Octavius
Ricky Gervais
Role: Dr. McPhee
Bill Hader
Role: George Armstrong Custer
Jon Bernthal
Role: Al Capone
Patrick Gallagher
Role: Attila the Hun
Jake Cherry
Role: Nicky Daley
Rami Malek
Role: Ahkmenrah
Mizuo Peck
Role: Sacajawea
Kerry van der Griend
Role: Neanderthal #1
Matthew Harrison
Role: Neanderthal #2
Rick Dobran
Role: Neanderthal #3
Jay Baruchel
Role: Sailor Joey Motorola
Keith Powell
Role: Tuskegee Airman #1
Craig Robinson
Role: Tuskegee Airman #2
Samuel Patrick Chu
Role: Teenage Boy #1
Augustus Oicle
Role: Teenage Boy #2
Kai James
Role: Teenage Boy #3
Clint Howard
Role: Air and Space Mission Control Tech #1
Matty Finochio
Role: Air and Space Mission Control Tech #2
George Foreman
Role: George Foreman
Josh Byer
Role: Capone Gangster #1
Sophie Levy
Role: Young Girl #1
Tess Levy
Role: Young Girl #2
Christina Schild
Role: 'American Gothic' Woman
Robert Thurston
Role: 'American Gothic' Farmer
Alberta Mayne
Role: Kissing Nurse
Clifton MaCabe Murray
Role: Kissing Sailor
Caroll Spinney
Role: Oscar the Grouch (voice)
Thomas Morley
Role: Darth Vader
Dan Joffre
Role: Town Car Driver
Dave Hospes
Role: Astronaut
Regina Taufen
Role: New York Reporter
Shawn Levy
Role: Infomercial Father
Joe Jonas
Role: Cherub #1 (voice)
Kevin Jonas
Role: Cherub #2 (voice)
Nick Jonas
Role: Cherub #3 (voice)
Eugene Levy
Role: Albert Einstein (voice)
Brad Garrett
Role: Easter Island Head (voice)
Ed Helms
Role: Larry Daley's Assistant (uncredited)
Jonah Hill
Role: Brundon the Security Guard (uncredited)
Thomas Lennon
Role: Wilbur Wright (uncredited)
Crystal the Monkey
Role: Dexter / Able (uncredited)