Gary Cooper
Role: Henry Louis 'Lou' Gehrig
Teresa Wright
Role: Eleanor Twitchell
Walter Brennan
Role: Sam Blake
Dan Duryea
Role: Hank Hanneman
Elsa Janssen
Role: Christina 'Mom' Gehrig
Ludwig Stössel
Role: Henry 'Pop' Gehrig
Virginia Gilmore
Role: Myra Tinsley
Bill Dickey
Role: Bill Dickey
Ernie Adams
Role: Miller Huggins
Pierre Watkin
Role: Mr. Twitchell
Harry Harvey
Role: Joe McCarthy
Bob Meusel
Role: Robert W. Meusel (as Robert W. Meusel)
Mark Koenig
Role: Mark Koenig
Bill Stern
Role: Bill Stern
Addison Richards
Role: Coach
Hardie Albright
Role: Van Tuyl
Edward Fielding
Role: Clinic Doctor
George Lessey
Role: Mayor of New Rochelle
Edgar Barrier
Role: Hospital Doctor
Douglas Croft
Role: Lou Gehrig as a Boy
Gene Collins
Role: Billy (Age 8)
David Holt
Role: Billy (Age 17)
Veloz
Role: Specialty Dancer (as Veloz and Yolanda)
Yolanda
Role: Specialty Dancer (as Veloz and Yolanda)
Ed Agresti
Role: Barber (uncredited)
Ernie Alexander
Role: Bellhop with Flowers (uncredited)
Hooper Atchley
Role: Lathered Man in Barber Shop (uncredited)
Edwin August
Role: Restaurant Patron (uncredited)
Bettye Avery
Role: Nightclub Singer (uncredited)
Becky Bohanon
Role: Little Girl (uncredited)
Lynton Brent
Role: Photographer in Hospital (uncredited)
Roy Brent
Role: Yankee Ballplayer (uncredited)
Betty Brewer
Role: Little Girl (uncredited)
Don Brodie
Role: Girl Show Barker (uncredited)
Charles Cane
Role: Plumber (uncredited)
Jack Carr
Role: Plumber (uncredited)
Burr Caruth
Role: Village Storekeeper (uncredited)
Eddy Chandler
Role: Motorcycle Cop #2 (uncredited)
Lane Chandler
Role: Mark - Player in Locker Room (uncredited)
Bill Chaney
Role: Newsboy (uncredited)
Jack Chapin
Role: Photographer (uncredited)
Janet Chapman
Role: Tessie (uncredited)
Spencer Charters
Role: Mr. Larsen (uncredited)
Porter Chase
Role: Weight Guesser (uncredited)
Dane Clark
Role: Fraternity Boy (uncredited)
Heinie Conklin
Role: Wallpaper Hanger (uncredited)
Hal Cooke
Role: Man in Cab (uncredited)
Clancy Cooper
Role: Motorcycle Cop #1 (uncredited)
John Daheim
Role: Reporter in Hospital (uncredited)
Eva Dennison
Role: Mrs. Worthington (uncredited)
Lester Dorr
Role: Disappointed Fan #1 (uncredited)
Peter Du Rey
Role: Photographer in Hospital (uncredited)
Lorna Dunn
Role: Clinic Nurse (uncredited)
Jim Farley
Role: Spectator (uncredited)
Frank Faylen
Role: Yankee Third Base Coach (uncredited)
Walter Fenner
Role: Dentist (uncredited)
Pat Flaherty
Role: Yankee Ballplayer (uncredited)
Rosina Galli
Role: Mrs. Fabrini (uncredited)
Vaughan Glaser
Role: Doctor in Gehrig Home (uncredited)
Mary Gordon
Role: Maid (uncredited)
Herschel Graham
Role: Spectator (uncredited)
George Guhl
Role: Second Paper Hanger (uncredited)
Eddie Hall
Role: Reporter in Hospital Room (uncredited)
Harry Hayden
Role: Department Store Manager (uncredited)
Vinton Hayworth
Role: Fraternity Boy (uncredited)
Oscar 'Dutch' Hendrian
Role: Furniture Mover (uncredited)
John Hiestand
Role: Announcer (uncredited)
Earle Hodgins
Role: Bottle Game Operator (uncredited)
Fay Holderness
Role: Spectator (uncredited)
John Ince
Role: Man in Box Seat (uncredited)
Mitchell Ingraham
Role: Barber (uncredited)
Charles Irwin
Role: Carnival Batting Game Operator (uncredited)
Jack Irwin
Role: Photographer in Hospital (uncredited)
Sheldon Jett
Role: Sportsman at Ballgame (uncredited)
Payne B. Johnson
Role: Boy in Ball Park (uncredited)
John Kellogg
Role: Fraternity Boy (uncredited)
Colin Kenny
Role: Yankee Player on Train (uncredited)
Donald Kerr
Role: Photographer (uncredited)
Richard Kipling
Role: Broker (uncredited)
Pat Lane
Role: Wheel of Chance Barker (uncredited)
Larry Lawson
Role: Barker (uncredited)
Rex Lease
Role: Spectator (uncredited)
Theodore Lorch
Role: Neighbor Leaning Through Window (uncredited)
Frank Lyman
Role: Fraternity Boy (uncredited)
Wilbur Mack
Role: Man Outside Yankee Stadium (uncredited)
Dave Manley
Role: Mayor Fiorello LaGuardia (uncredited)
Maurice Marks
Role: Player (uncredited)
Francisco Marán
Role: Rathskeller Headwaiter (uncredited)
John C. McCallum
Role: Minor Role (uncredited)
Ralph McCullough
Role: Reporter in Hospital (uncredited)
George McDonald
Role: Wally Pipp (uncredited)
Matt McHugh
Role: Strength Machine Operator (uncredited)
James McNamara
Role: Rathskeller Manager (uncredited)
Wilmuth Merkyl
Role: Spectator (uncredited)
Howard M. Mitchell
Role: Sportsman at Ballgame (uncredited)
Irving Mitchell
Role: Headwaiter (uncredited)
Pat Moriarity
Role: Policeman in 1915 (uncredited)
Tom Neal
Role: Fraternity Boy (uncredited)
Ray Noble
Role: Orchestra Leader (uncredited)
Patsy O'Byrne
Role: Scrubwoman (uncredited)
George Offerman, Jr.
Role: Freshman (uncredited)
John B. Old
Role: Reporter (uncredited)
Garry Owen
Role: Scorecard Vendor (uncredited)
Sarah Padden
Role: Mrs. Roberts (uncredited)
Emory Parnell
Role: Chicago Policeman O'Doul (uncredited)
Edward Peil Sr.
Role: Policeman (uncredited)
Tom Quinn
Role: Reporter in Hospital (uncredited)
Cyril Ring
Role: Photographer (uncredited)
Henry Roquemore
Role: Disappointed Fan #2 (uncredited)
Art Rowlands
Role: Telephone Man (uncredited)
William Roy
Role: Joe Fabrini (uncredited)
Rip Russell
Role: Laddie (uncredited)
Francis Sayles
Role: Cab Driver (uncredited)
Anita Sharp-Bolster
Role: Sasha's Mother (uncredited)
C. Montague Shaw
Role: Mr. Worthington (uncredited)
Jack Shea
Role: Hammond (uncredited)
John Sheehan
Role: First Paper Hanger (uncredited)
Jack Stewart
Role: Ed Barrow (uncredited)
Brick Sullivan
Role: Policeman (uncredited)
Ben Taggart
Role: Conductor (uncredited)
Walter Tetley
Role: Cake Delivery Boy (uncredited)
Jimmy Valentine
Role: Sasha - Boy Playing Baseball (uncredited)
Gohr Van Vleck
Role: Furniture Mover (uncredited)
Dorothy Vaughan
Role: Eleanor's Landlady (uncredited)
Dorothy Vernon
Role: Family Friend (uncredited)
Malcolm Waite
Role: Big Strength Machine Contestant (uncredited)
James Westerfield
Role: Spectator (uncredited)
Guy Wilkerson
Role: Sportsman at Ballgame (uncredited)
Max Willenz
Role: Mr. Colletti (uncredited)
Buddy Williams
Role: Bootblack (uncredited)
Charles Williams
Role: Little Strength Machine Contestant (uncredited)
Robert Winkler
Role: Murphy (uncredited)
Allen Wood
Role: Freshman (uncredited)
Dick Gordon
Role: Radio Listener (uncredited)
Charles Flynn
Role: Fraternity Boy (uncredited)
Anthony Walters
Role: Merril (uncredited)
