Diego Luna
Role: Manolo (voice)
Channing Tatum
Role: Joaquin (voice)
Zoe Saldaña
Role: Maria (voice)
Christina Applegate
Role: Mary Beth (voice)
Eugenio Derbez
Role: Chato (voice)
Cheech Marin
Role: Pancho Rodriguez (voice)
Gabriel Iglesias
Role: Pepe Rodriguez (voice)
Ron Perlman
Role: Xibalba (voice)
Kate del Castillo
Role: La Muerte (voice)
Ana de la Reguera
Role: Carmen Sánchez (voice)
Dan Navarro
Role: Chakal (voice)
Ice Cube
Role: Candle Maker (voice)
Héctor Elizondo
Role: Carlos Sanchez (voice)
Danny Trejo
Role: Skeleton Luis (voice)
Carlos Alazraqui
Role: General Posada / Dali / Chuy (voice)
Emil-Bastien Bouffard
Role: Young Manolo (voice)
Elijah Rodriguez
Role: Young Joaquin
Genesis Ochoa
Role: Young Maria (voice)
Plácido Domingo
Role: Skeleton Jorge (voice)
Grey DeLisle
Role: Grandmother (voice) (as Grey Griffin)
Trey Bumpass
Role: Goth Kid / Orphan
Miguel Sandoval
Role: Land of the Remembered Captain (voice)
Ben Gleib
Role: Goya / Dali (voice)
Ricardo El Mandril Sanchez
Role: Pablo Rodriguez (voice)
Jorge R. Gutierrez
Role: Skeleton Carmelo (voice)
Anjelah Johnson-Reyes
Role: Adelita / Nina (voice)
Kennedy Peil
Role: Sasha (voice)
Sandra Equihua
Role: Scardelita (voice)
Callahan Clark
Role: Jane (voice)
Gunnar Sizemore
Role: Ignacio (voice)
Angélica María
Role: Sister Ana (voice)
Eric Bauza
Role: Father Domingo / Cave Guardian (voice)
Aron Warner
Role: Thomas (voice)
Sandra Echeverría
Role: Claudia (voice)
Tonita Castro
Role: La Muerte as Old Woman (voice)
Troy Evans
Role: Old Man Hemingway (voice)
Guillermo del Toro
Role: Land of the Remembered Captain's Wife (voice)
Brad Booker
Role: Conductor (voice)
Rosemary Alexander
Role: Additional Voices (voice)
Steve Alterman
Role: Additional Voices (voice)
Eva Bella
Role: Additional Voices (voice)
Madison Carlon
Role: Additional Voices (voice)
Vicki Davis
Role: Additional Voices (voice)
Moosie Drier
Role: Additional Voices (voice)
Cullen McCarthy
Role: Additional Voices (voice)
David Michie
Role: Additional Voices (voice)
Michelle Moores
Role: Additional Voices (voice)
Jonathan Nichols-Navarro
Role: Additional Voices (voice)
Al Rodrigo
Role: Additional Voices (voice)
Marcelo Tubert
Role: Additional Voices (voice)
Lynnanne Zager
Role: Additional Voices (voice)
Ruth Zalduondo
Role: Additional Voices (voice)
Newell Alexander
Role: Additional Voices (voice)
David Cowgill
Role: Additional Voices (voice)
Elisa Gabrielli
Role: Additional Voices (voice)
Richard Miro
Role: Additional Voices (voice)
Arthur Ortiz
Role: Additional Voices (voice)
Nathaniel Semsen
Role: Additional Voices (voice)
Joe Matthews
Role: Young Manolo (singer)
Jose Alvarez
Role: Additional Voices (voice) (uncredited)
