David Mattey
Role: Toxic Avenger / Noxious Offender
Debbie Rochon
Role: Ms. Weiner
Clyde Lewis
Role: Toxie (voice)
Heidi Sjursen
Role: Sarah / Claire
Ron Jeremy
Role: Mayor Goldberg
Paul Kyrmse
Role: Sgt. Kabukiman / Evil Kabukiman
Stan Lee
Role: Prologue / Epilogue Narrator (voice)
Joe Fleishaker
Role: Chester / Lardass
Dan Snow
Role: Sgt. Kazinski
Michael Budinger
Role: Tito
Lisa Terezakis
Role: Sweetie Honey
Corey Feldman
Role: Sarah's Gynecologist
Trent Haaga
Role: Tex Diaper
Mark Torgl
Role: Evil Melvin
Rick Collins
Role: Amortville Police Chief
Lisa Gaye
Role: Abortion Counselor
James Gunn
Role: Dr. Flem Hocking
Al Goldstein
Role: Press Secretary
Taylor Mead
Role: Award Presenter
Yaniv Sharon
Role: Rex Diaper
Will Keenan
Role: Man Hit by Car
Melissa Bacelar
Role: Dr. Hocking's Nurse
Jasi Cotton Lanier
Role: Wet Lesbian
Lemmy Kilmister
Role: Good Lemmy / Bad Lemmy
Julie Strain
Role: Herself (Facelift Death)
Kevin Eastman
Role: Himself (Breast Smoosh Death)
Tiffany Shepis
Role: Beautiful Interpretative Dancer
Eli Roth
Role: Beautiful Young Boy
Hugh Hefner
Role: President of the United States
Charlotte Kaufman
Role: Tromaville / Amortville Citizen
Lloyd Kaufman
Role: Man in Public Service Announcement
Neriah Davis
Role: Glamorous Gyno-American
Devin DeVasquez
Role: Glamorous Gyno-American
Taimie Hannum
Role: Glamorous Gyno-American
Masuimi Max
Role: Glamorous Gyno-American
Doria Rone
Role: Glamorous Gyno-American
Petra Verkaik
Role: Glamorous Gyno-American
Hank the Angry Drunken Dwarf
Role: God
Celeste Octavia
Role: Glamorous Gyno-American / Naked Nurse (as Celeste Octavian)
Tromelissa Saytar
Role: Lesbian Art Student
Terri Firmer
Role: Wet Lesbian / Topless Deaf Translator
Bella Compagna
Role: Diaper Mafia Temptress
Brandi Brandt
Role: Glamorous Gyno-American
Randy Sklar
Role: Randy Diaz
Jason Sklar
Role: Jason Gonzalez
Crystal McCloud
Role: Nurse
Joe James
Role: Tromaville Nazi #2
Matthew Goldpaugh
Role: Tromaville Nazi - Angry Tromaville Citizen- Amortvillain
