Alec Baldwin
Role: Theodore Templeton (voice)
Steve Buscemi
Role: Francis E. Francis (voice)
Miles Bakshi
Role: Tim Templeton (voice)
Jimmy Kimmel
Role: Ted Templeton (voice)
Lisa Kudrow
Role: Janice Templeton (voice)
Tobey Maguire
Role: Narrator / Older Tim Templeton (voice)
Conrad Vernon
Role: Eugene Francis (voice)
James McGrath
Role: Wizzie / Elvis Impersonator (voice)
David Soren
Role: Jimbo (voice)
Nina Zoe Bakshi
Role: Tim's Daughter / Girl / Little Girl (voice)
Tom McGrath
Role: TV Chef (voice)
Walt Dohrn
Role: Photographer (voice)
James Ryan
Role: Story Bear (voice)
Eric Bell Jr.
Role: Triplets (voice)
ViviAnn Yee
Role: Staci (voice)
Edie Mirman
Role: Big Boss Baby (voice)
James Izzo
Role: Elvis impersonator (voice)
Chris Miller
Role: Captain Ross (voice)
Chloe Albrecht
Role: Hazmat Baby (voice)
Andrea Montana Knoll
Role: Flight Attendant (voice)
Joseph Izzo
Role: Elvis Impersonators (voice)
Glenn Harmon
Role: Airport Announcer (voice)
Brian Hopkins
Role: Airport Security Guard (voice)
Jules Winter
Role: Crying Boy / Little Boy / Boy (voice)