Sarah Silverman
Role: Self
Nathan Barnatt
Role: Homeless Man (segment "Lisa")
Lauren Lapkus
Role: Girl 5 (segment "Lisa")
John C. Reilly
Role: Father (segment "Ham")
Laura Silverman
Role: Self (segment "Knickers")
Seth Rogen
Role: Officer Durand (segment "Knickers")
Jade Catta-Preta
Role: Mother (segment "Lisa")
Natasha Leggero
Role: Girl 2 (segment "Lisa")
Shelby Fero
Role: Girl 1 (segment "Lisa")
Nathan Fielder
Role: Self (segment "Retro Video Arcade")
David Dineen-Porter
Role: Self (segment "Retro Video Arcade")
Michael Daniel Cassady
Role: Self (segment "Lisa")
Emily Maya Mills
Role: Girl 6 (segment "Lisa")
Nick Rutherford
Role: Father (segment "Lisa")
Paul Rust
Role: Self (segment "Lisa")
Armen Weitzman
Role: Mailman
Kulap Vilaysack
Role: Girl 3 (segment "Lisa")
Harris Wittels
Role: Scientist 1 (segment "CCDF")
Tig Notaro
Role: Girl 4 (segment "Lisa")
Grace Helbig
Role: Bride 5 (segment "Absorption")
2 Chainz
Role: Self (segment "Absorption")
Casey Ford Alexander
Role: Bad Guy 2 (segment "CCDF")
Jack Bornoff
Role: Tomato Man (segment "Ham")
Hailey Boyle
Role: Cashier (segment "Knickers")
Aaron Chrenen
Role: Cooper (segment "Ginger Orphan Playhouse") (voice)
Larry A. Davies
Role: Lloyd (segment "Absorption")
Greg Davis Jr.
Role: Groom 2 (segment "Absorption")
Donna DuBain
Role: Madame Trinkett (segment "Ginger Orphan Playhouse") (voice)
Trevor Eyster
Role: Bad Guy 1 (segment "CCDF")
Malinda Farrington
Role: Malinda (segment "Ham")
Kate Freund
Role: Prostitute (segment "CCDF")
David Garcia
Role: Bad Guy 3 (segment "CCDF")
Cyrus Ghahremani
Role: Self
Hannah Hart
Role: Bride 4 (segment "Absorption")
Deloris Heard
Role: Customer (segment "Knickers")
Pamela Immel
Role: Pamela (segment "Ham")
Zack Kennedy
Role: Band Member 4 (segment "Absorption")
Keegan-Michael Key
Role: Self (segment "Absorption")
Ben Lepley
Role: Vacuum Salesman (segment "Ginger Orphan Playhouse") (voice)
Catherine Lydon
Role: Cashier (segment "Ham")
Rasika Mathur
Role: Bride 3 (segment "Absorption")
Kyle Pacek
Role: Son (segment "Ham")
Sandeep Parikh
Role: Groom 3 (segment "Absorption")
Jordan Peele
Role: Self (segment "Absorption")
Issa Rae
Role: Bride 2 (segment "Absorption")
Ron Ransen
Role: Band Member 1 (segment "Absorption")
Willy Roberts
Role: Taco Truck Worker (segment "CCDF")
Chase Stewart
Role: Son (segment "Lisa")
Mark Taormino
Role: Band Member 2 (segment "Absorption")
Brittani Taylor
Role: Bride 1 (segment "Absorption")
Aono Tetsuji
Role: Bad Guy 4 (segment "CCDF")
James Trenton
Role: James (segment "Ham")
Jack Vale
Role: Groom 1 (segment "Absorption")
