Harry Connick Jr.
Role: Dr. Dennis Slamon
Tammy Blanchard
Role: Nicole Wilson
Amanda Bynes
Role: Jamie McGrath
Jennifer Coolidge
Role: Tish
Angie Harmon
Role: Lilly Tartikoff
John Benjamin Hickey
Role: Blake Rogers
Regina King
Role: Ellie Jackson
Swoosie Kurtz
Role: Elizabeth
Paula Cale
Role: Donna Slamon (as Paula Cale Lisbe)
Amy Madigan
Role: Fran Visco
Bernadette Peters
Role: Barbara Bradfield
Melissa McBride
Role: Sally
J. Patrick McNamara
Role: Dr. Rice
Brandon Smith
Role: Pharmacy Board Member
Bruce McKinnon
Role: Dean Bradfield
Tom Nowicki
Role: Carl Reinhardt
William Ragsdale
Role: Andy Marks
Naima Lett
Role: Nurse Carol (as Naima Imani Lett)
Griff Furst
Role: Charlie Wilson
Joe Nemmers
Role: Ron Perelman
Rhoda Griffis
Role: Bindy Blake
Lance E. Nichols
Role: Dr. Brown
Louis Herthum
Role: Dr. Banks
Connor Hill
Role: Sam Wilson Age 5
Tyler Case
Role: Sam Wilson Age 7 and 8
Cooper Cason
Role: Sam Wilson Age 14
Sophia Watson
Role: Joey Lyn Slamon Age 7
Abby Rao
Role: Joey Lyn Slamon Age 9
Sam Richardson
Role: Matt Slamon Age 3 - 5
Ben Lux
Role: Matt Slamon Age 7 (as Benjamin Lux)
Austin Lux
Role: Matt Slamon Age 9
Elliott Grey
Role: Board Member
Andrew Matthews
Role: Darrin Bradfield
Evan Gamble
Role: Peter Wilson
Shanna Forrestall
Role: Runner