John Wayne
Role: John Chisum
Forrest Tucker
Role: Lawrence Murphy
Christopher George
Role: Dan Nodeen
Ben Johnson
Role: James Pepper
Glenn Corbett
Role: Pat Garrett
Andrew Prine
Role: Alex McSween
Bruce Cabot
Role: Sheriff Brady
Patric Knowles
Role: Henry Tunstall
Richard Jaeckel
Role: Jess Evans
Lynda Day George
Role: Sue McSween
Geoffrey Deuel
Role: Billy 'The Kid' Bonney
Pamela McMyler
Role: Sallie Chisum
John Agar
Role: Amos Patton
Lloyd Battista
Role: Neemo
Robert Donner
Role: Bradley Morton
Christopher Mitchum
Role: Tom O'Folliard
Edward Faulkner
Role: James J. Dolan
Ray Teal
Role: Justice J.B. Wilson
Ron Soble
Role: Charley Bowdre
Glenn Langan
Role: Colonel Nathan Dudley
Alan Baxter
Role: Gov. Sam Axtell
Alberto Morin
Role: Juan Delgado
William Bryant
Role: Jeff - Head Wrangler
Pedro Armendáriz Jr.
Role: Ben
John Pickard
Role: Sgt. Braddock
Abraham Sofaer
Role: Chief White Buffalo
Gregg Palmer
Role: Karl Riker
Hank Worden
Role: Stationmaster Elwood
Pedro Gonzalez Gonzalez
Role: Mexican Rancher
Jim Burk
Role: Trace - Wrangler
Bob Morgan
Role: Pegleg on Street
William Conrad
Role: Narrator - Opening Credits (voice) (uncredited)
José Ángel Espinosa 'Ferrusquilla'
Role: Governor's Aide (uncredited)
Ron Fletcher
Role: Doctor (uncredited)
'Chico' Hernandez
Role: Boy on Town (uncredited)
John Kelly
Role: Minister (uncredited)
Cliff Lyons
Role: Wrangler (uncredited)
Josh McLaglen
Role: Young Boy Loading Wagon (uncredited)
Mary McLaglen
Role: Young Girl (uncredited)
Lee Meriwether
Role: Sallie's Mother (picture in Chisum's Pocketwatch) (uncredited)
Chuck Roberson
Role: Trail Herder (uncredited)
José Torvay
Role: Mexican Blacksmith (uncredited)
José Trinidad Villa
Role: Blacksmith (uncredited)
Ralph Volkie
Role: Blacksmith (uncredited)
Henry Wills
Role: Extra (uncredited)