James Stewart
Role: Tom Destry Jr.
Marlene Dietrich
Role: Frenchy
Charles Winninger
Role: Washington Dimsdale
Allen Jenkins
Role: Gyp Watson
Warren Hymer
Role: Bugs Watson
Irene Hervey
Role: Janice Tyndall
Una Merkel
Role: Lily Belle
Billy Gilbert
Role: Loupgerou
Samuel S. Hinds
Role: Judge Slade
Jack Carson
Role: Jack Tyndall
Tom Fadden
Role: Lem Claggett
Virginia Brissac
Role: Sophie Claggett
Edmund MacDonald
Role: Rockwell (as Edmund Macdonald)
Joe King
Role: Sheriff Keogh
Dickie Jones
Role: Claggett Boy
Ann E. Todd
Role: Claggett Girl
Richard Alexander
Role: Cowboy (uncredited)
Silver Tip Baker
Role: Barfly (uncredited)
Chief John Big Tree
Role: Indian in Saloon (uncredited)
Billy Bletcher
Role: Pianist (uncredited)
Loren Brown
Role: Juggler (uncredited)
Buck Bucko
Role: Barfly (uncredited)
Roy Bucko
Role: Barfly (uncredited)
George Chesebro
Role: Barfly (uncredited)
Dora Clement
Role: Woman (uncredited)
Bill Cody Jr.
Role: Townsboy Telling Wash of Destry's Arrival (uncredited)
Spade Cooley
Role: Fiddle Player (uncredited)
Harry Cording
Role: Creepy - Lends Tom Guns (uncredited)
Carmen D'Antonio
Role: Dancer (uncredited)
Harold DeGarro
Role: Juggler (uncredited)
Tex Driscoll
Role: Barfly (uncredited)
Florence Dudley
Role: Small Role (uncredited)
Ruth Eddings
Role: Friend of Lilly Belle (uncredited)
O.K. Ford
Role: Barfly (uncredited)
Sam Garrett
Role: Rider / Roper (uncredited)
William Gillis
Role: Barfly (uncredited)
Jack Gordon
Role: Barfly (uncredited)
Lloyd Ingraham
Role: Express Agent with Box of Rabbits (uncredited)
Marjorie Kane
Role: Saloon Floozie (uncredited)
Harley Luse
Role: Accordion Player (uncredited)
Cactus Mack
Role: Musician (uncredited)
Frank McCarroll
Role: Barfly (uncredited)
Bud McClure
Role: Stage Driver (uncredited)
Merrill McCormick
Role: Townsman (uncredited)
Philo McCullough
Role: Bartender (uncredited)
Robert McKenzie
Role: Doctor (uncredited)
Charles Murphy
Role: Townsman (uncredited)
Mary Shannon
Role: Woman on Street (uncredited)
Rudy Sooter
Role: Bass Player (uncredited)
Betta St. John
Role: Singing Girl in Wagon (uncredited)
William Steele
Role: Cowboy (uncredited)
Leo Sulky
Role: Bartender (uncredited)
Al Taylor
Role: Townsman (uncredited)
Harry Tenbrook
Role: Stage Shotgun Rider
Jack Tornek
Role: Barfly (uncredited)
Minerva Urecal
Role: Mrs. DeWitt (uncredited)
Leslie Vincent
Role: (uncredited)
Hank West
Role: Musician (uncredited)
Dan White
Role: Barfly (uncredited)
Blackie Whiteford
Role: Juror (uncredited)
Alex Woloshin
Role: Assistant Bartender (uncredited)
Duke York
Role: Townsman (uncredited)
