Keanu Reeves
Role: Neo ("Kid's Story") (voice)
Carrie-Anne Moss
Role: Trinity ("Kid's Story" and "A Detective Story") (voice)
Clayton Watson
Role: The Kid ("Kid's Story") (voice)
Pamela Adlon
Role: Jue ("Final Flight of the Osiris") / Manabu ("Beyond") (voice)
Melinda Clarke
Role: Alexa ("Matriculated") (voice)
John DiMaggio
Role: Crew Man ("Final Flight of the Osiris") / Kaiser ("Program") (voice)
Kevin Michael Richardson
Role: Thadeus ("Final Flight of Osiris") / Cop ("Kid's Story") / Agent #2 ("World Record")
Tom Kenny
Role: Operator ("Final Flight of Osiris")
Rick Gomez
Role: Pilot ("Final Flight of Osiris")
Tara Strong
Role: Crew Woman ("Final Flight of Osiris") / Nurse ("World Record") / Misha ("Beyond")
Bette Ford
Role: Old Woman ("Final Flight of Osiris")
Julia Fletcher
Role: The Instructor ("The Second Renaissance Part I & II") / Narrator ("World Record")
Dane A. Davis
Role: 01 Versatran Spokesman ("The Second Renaissance Part I & II")
Debi Derryberry
Role: Kid ("The Second Renaissance Part I & II")
Jill Talley
Role: Mother ("The Second Renaissance Part I & II")
Dwight Schultz
Role: Additional Voices ("The Second Renaissance Part I & II") / Monaka ("Matriculated")
James Arnold Taylor
Role: Additional Voices ("The Second Renaissance Part I & II") / Ash ("A Detective Story") / Raul ("Matriculated")
John DeMita
Role: Teacher ("Kid's Story")
Hedy Burress
Role: Cis ("Program") / Yoko ("Beyond")
Phil LaMarr
Role: Duo ("Program")
Victor Williams
Role: Dan ("World Record")
John Wesley
Role: Dan's Dad ("World Record")
Alex Fernandez
Role: Tom ("World Record")
Allison Smith
Role: Reporter ("World Record")
Matt McKenzie
Role: Agent #1 ("World Record") / Agent ("Beyond") / Agent ("A Detective Story")
Tress MacNeille
Role: Housewife ("Beyond") / Kenny ("Beyond")
Kath Soucie
Role: Pudgy ("Beyond") / Masa ("Beyond") / Sara ("Beyond")
Terrence 'T.C.' Carson
Role: Clarence ("A Detective Story")
Rodney Saulsberry
Role: Chyron ("Matriculated")
Olivia d'Abo
Role: Rox ("Matriculated")
Jack Fletcher
Role: Sandro ("Matriculated")
Akio Otsuka
Role: Thadeus (voice)
