Keir Dullea
Role: Dr. David Bowman
Gary Lockwood
Role: Dr. Frank Poole
William Sylvester
Role: Dr. Heywood Floyd
Douglas Rain
Role: HAL 9000 (voice)
Daniel Richter
Role: Moonwatcher
Leonard Rossiter
Role: Dr. Andrei Smyslov
Margaret Tyzack
Role: Elena
Robert Beatty
Role: Dr. Ralph Halvorsen
Sean Sullivan
Role: Dr. Roy Michaels
Frank W. Miller
Role: Mission Controller (voice)
Bill Weston
Role: Astronaut
Ed Bishop
Role: Aries-1B Lunar Shuttle Captain
Glenn Beck
Role: Astronaut
Alan Gifford
Role: Poole's Father
Ann Gillis
Role: Poole's Mother
Edwina Carroll
Role: Aries-1B Stewardess
Penny Brahms
Role: Stewardess
Heather Downham
Role: Stewardess
Mike Lovell
Role: Astronaut
Terry Duggan
Role: Ape Attacked by Leopard
Laurence Marchant
Role: Ape
Richard Woods
Role: Ape Killed by Moon-Watcher
Maggie London
Role: Hostess in Elevator (uncredited)
Chela Matthison
Role: Receptionist (uncredited)
Judy Keirn
Role: Voice Print Identification Girl (uncredited)
Vivian Kubrick
Role: Floyd's Daughter (uncredited)
Kenneth Kendall
Role: BBC-12 Announcer (uncredited)
Kevin Scott
Role: Miller (uncredited)
Martin Amor
Role: Interviewer (uncredited)
S. Newton Anderson
Role: Young Man (uncredited)
Sheraton Blount
Role: (uncredited)
Ann Bormann
Role: (uncredited)
Julie Croft
Role: (uncredited)
Penny Francis
Role: (uncredited)
Marcella Markham
Role: (uncredited)
Irena Marr
Role: Russian Scientist (uncredited)
Krystyna Marr
Role: Russian Scientist (uncredited)
Kim Neil
Role: (uncredited)
Jane Pearl
Role: (uncredited)
Penny Pearl
Role: (uncredited)
Burnell Tucker
Role: TMA-1 Site Photographer (uncredited)
John Swindells
Role: TMA-1 Site Technician #1 (uncredited)
John Clifford
Role: TMA-1 Site Technician #2 (uncredited)
Stanley Kubrick
Role: Astronaut Breathing (voice) (uncredited)
Harry Fielder
Role: Moonwalker (uncredited)
