Roberto Benigni
Role: Roberto (segment "Strange to Meet You")
Steven Wright
Role: Steven (segment "Strange to Meet You")
Joie Lee
Role: Good Twin (segment "Twins")
Cinqué Lee
Role: Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")
Steve Buscemi
Role: Danny (segment "Twins")
Iggy Pop
Role: Iggy (segment "Somewhere in California")
Tom Waits
Role: Tom (segment "Somewhere in California")
Joseph Rigano
Role: Joe (segment "Those Things'll Kill Ya")
Vinny Vella
Role: Vinny (segment "Those Things'll Kill Ya")
Vinny Vella, Jr.
Role: Vinny Jr. (segment "Those Things'll Kill Ya")
Renée French
Role: Renée (segment "Renée")
E.J. Rodriguez
Role: Waiter (segment "Renée")
Alex Descas
Role: Alex (segment "No Problem")
Isaach de Bankolé
Role: Isaach (segment "No Problem")
Cate Blanchett
Role: Cate / Shelly (segment "Cousins")
Michael Hogan
Role: Waiter (segment "Cousins")
Jack White
Role: Jack (segment "Jack Shows Meg His Tesla Coil")
Meg White
Role: Meg (segment "Jack Shows Meg His Tesla Coil")
Alfred Molina
Role: Alfred (segment "Cousins?")
Steve Coogan
Role: Steve (segment "Cousins?")
Katy Hansz
Role: Katy (segment "Cousins?")
The GZA
Role: GZA (segment "Delirium")
RZA
Role: RZA (segment "Delirium")
Bill Murray
Role: Bill Murray (segment "Delirium")
William Rice
Role: Bill (segment "Champagne")
Taylor Mead
Role: Taylor (segment "Champagne")
