Daniel Radcliffe
Role: 'Weird Al' Yankovic
Evan Rachel Wood
Role: Madonna
Rainn Wilson
Role: Dr. Demento
Toby Huss
Role: Nick Yankovic
Spencer Treat Clark
Role: Steve
Tommy O'Brien
Role: Bermuda
Arturo Castro
Role: Pablo Escobar
Julianne Nicholson
Role: Mary Yankovic
Diedrich Bader
Role: Grizzled Narrator (voice)
Lin-Manuel Miranda
Role: Doctor
Richard Aaron Anderson
Role: Young Al
Thomas Lennon
Role: Salesman
David Bloom
Role: Teenage Al
Keanush Tafreshi
Role: Kip
Andrew Steven Hernandez
Role: Robbie
Paloma Esparza Rabinov
Role: Hipster Teen
Scott Aukerman
Role: Police Officer
Johnny Pemberton
Role: Johnny Barf
Jonah Ray Rodrigues
Role: Jonah Barf
Jeremy Bolm
Role: Jeremy Barf
Eric Appel
Role: Captain Buffoon (voice)
'Weird Al' Yankovic
Role: Tony Scotti
Will Forte
Role: Ben Scotti
Patton Oswalt
Role: Heckler
Michael McKean
Role: Sleazy MC
Dot-Marie Jones
Role: Mama Bear
Dean Sharpe
Role: Bartender
Jorma Taccone
Role: Pee-Wee Herman
Demetri Martin
Role: Tiny Tim
Paul F. Tompkins
Role: Gallagher
Akiva Schaffer
Role: Alice Cooper
Conan O'Brien
Role: Andy Warhol
Emo Philips
Role: Salvador Dali
Jack Black
Role: Wolfman Jack
David Dastmalchian
Role: John Deacon
Anthony N.
Role: Security Guard
Quinta Brunson
Role: Oprah Winfrey
Julie Chang
Role: Connie Chung
Seth Green
Role: Radio DJ (voice)
Constantine Rousouli
Role: Cone-Bra Dancer #1
James Brown III
Role: Cone-Bra Dancer #2
Rocky Abou-Sakher
Role: Terrorist Diner Patron
Chris Ryan
Role: Kidnapper
Mike Escamilla
Role: Guard #1
Chad Guerrero
Role: Guard #2
Cesar Ramirez
Role: Mariachi Band Member #1
Omar Estrada
Role: Mariachi Band Member #2
Cesar Chavira
Role: Mariachi Band Member #3
Jimmy Walker Jr.
Role: Floor Manager
James Preston Rogers
Role: Hulk Hogan
William Guirola
Role: Sicario
Paul Riley Fox
Role: Elton John (uncredited)
Gordon Tarpley
Role: David Bowie (uncredited)
Lisa Margaroli
Role: Elvira, Mistress of the Dark (uncredited)
Erin O'Shea
Role: Kate Pierson (uncredited)
James Hunter
Role: Paparazzi (uncredited)
