Zach Tyler Eisen
Role: Lucas Nickle (voice)
Julia Roberts
Role: Hova (voice)
Meryl Streep
Role: Queen (voice)
Nicolas Cage
Role: Zoc (voice)
Paul Giamatti
Role: Stan Beals (voice)
Bruce Campbell
Role: Fugax (voice)
Regina King
Role: Kreela (voice)
Lily Tomlin
Role: Mommo (voice)
Larry Miller
Role: Fred Nickle (voice)
Cheri Oteri
Role: Doreen Nickle (voice)
Ricardo Montalban
Role: Head of Council (voice)
Myles Jeffrey
Role: Steve (voice)
Creagen Dow
Role: Mullet Boy (voice)
Frank Welker
Role: Spindle / Frog / Caterpillar (voice)
Mark DeCarlo
Role: Fly (voice)
Jake T. Austin
Role: Nicky (voice)
Allison Mack
Role: Tiffany Nickle (voice)
S. Scott Bullock
Role: Glow Worm / Wasp Survivor (voice)
Paul Greenberg
Role: Sleeping Ant #1 / Head Lice #1 / Head Lice #2 / Head Lice #3 / Head Lice #4 / Brett (voice)
Rob Paulsen
Role: Beetle (voice)
Nicole Sullivan
Role: Ant #9 (voice)
Don Frye
Role: Soldier Ant (voice)
Larry Cedar
Role: Ant #8 (voice)
Paul Greenberg
Role: Sleeping Ant #1 / Head Lice #1 / Head Lice #2 (voice)
David Kaye
Role: Sleeping Ant #2 / Guard Ant #3 / Wrangler Ant (voice)
Alfred Jackson
Role: Slacker Ant (voice)
Ken Mitchroney
Role: Ant #17 / Guard Ant #2 / Wasp #8 (voice)
Denzel Whitaker
Role: Albert (voice)
Casey Masamitsu
Role: Shigeko (voice)
Bryan Fabian
Role: Fernando (voice)
Jake Goldberg
Role: Helmet Boy / Nob / Red Teammate #1 (voice)
Keith Alcorn
Role: Ant #18 / Pupa / Soldier Ant #3 (voice)
John A. Davis
Role: Ant #19 (voice)
Tom Kenny
Role: Drone Ant / Ant #2 / Ant #6 (voice)
Sarah Mensinga
Role: Mother Ant (voice)
Nika Futterman
Role: Ant #1 / Ant #7 (voice)
Scott Holst
Role: Ant #3 (voice)
Susan Silo
Role: Ant #4 (voice)
Paul Rugg
Role: Ant #5 (voice)
Candi Milo
Role: Nurse Ant #3 (voice)
Nissa Alcorn
Role: Billo (voice)
Pat Fraley
Role: Ant Council #1 (voice)
Tyler James Williams
Role: Blue Teammate #1 (voice)
Jared Goldsmith
Role: Blue Teammate #2 / Red Teammate #2 (voice)
Austin Majors
Role: Blue Teammate #3 (voice)
Jaishon Fisher
Role: Blue Teammate #4 (voice)
Aaron Michael Drozin
Role: Blue Teammate #5 (voice)
Max Burkholder
Role: Blue Teammate #6 (voice)
Sam Green
Role: Red Teammate #3 (voice)
Colin Ford
Role: Red Teammate #4 (voice)
Kendall Ryan Sanders
Role: Red Teammate #5 (voice)
Shane Baumel
Role: Red Teammate #6 (voice)
Neil Ross
Role: Wasp #1 / Wasp #5 (voice)
Bob Joles
Role: Wasp #2 (voice)
Wally Wingert
Role: Wasp #3 (voice)
Leon Morenzie
Role: Wasp #4 (voice)
Jonathan David Cook
Role: Wasp #6 (voice)
Sean Donnellan
Role: Soldier Ant #1 (voice)
Tress MacNeille
Role: Old Council Ant (voice)
Richard Green
Role: Wasp Leader (voice)
Clive Robertson
Role: Hova's Wasp (voice)
Vernee Watson-Johnson
Role: Head Nurse (voice)
