Dan Castellaneta
Role: Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice)
Julie Kavner
Role: Marge Simpson / Selma Bouvier / Patty Bouvier (voice)
Nancy Cartwright
Role: Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice)
Yeardley Smith
Role: Lisa Simpson (voice)
Hank Azaria
Role: Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice)
Harry Shearer
Role: Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice)
Pamela Hayden
Role: Milhouse Van Houten / Jimbo Jones / Rod Flanders (voice)
Tress MacNeille
Role: Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)
Albert Brooks
Role: Russ Cargill (voice)
Karl Wiedergott
Role: Man / EPA Driver (voice)
Marcia Wallace
Role: Edna Krabappel (voice)
Russi Taylor
Role: Martin Prince (voice)
Maggie Roswell
Role: Helen Lovejoy (voice)
Phil Rosenthal
Role: TV Dad (voice)
Billie Joe Armstrong
Role: Billie Joe Armstrong (voice)
Mike Dirnt
Role: Mike Dirnt (voice)
Tré Cool
Role: Tre Cool (voice)
Joe Mantegna
Role: Fat Tony (voice)
Tom Hanks
Role: Tom Hanks (voice)
