Hank Azaria
Role: Gargamel
Neil Patrick Harris
Role: Patrick Winslow
Jayma Mays
Role: Grace Winslow
Jonathan Winters
Role: Papa Smurf (voice)
Katy Perry
Role: Smurfette (voice)
Anton Yelchin
Role: Clumsy Smurf (voice)
Sofía Vergara
Role: Odile Anjelou
Frank Welker
Role: Azrael (voice)
Madison McKinley
Role: Model
Mahadeo Shivraj
Role: Cabbie
Julie Chang
Role: Newscaster
Mark Doherty
Role: Bluetooth Businessman
Minglie Chen
Role: Young Woman
Sean Kenin
Role: Guy in Plaid Shirt
Adria Baratta
Role: Anjelou Employee
Paula Pizzi
Role: Odile's Mother
Andrew Sellon
Role: Waiter
Julianna Rigoglioso
Role: Little Sister
Daria Rae Figlo
Role: Blonde Sister
Bradley Gosnell
Role: Toy Salesperson
Heidi Armbruster
Role: Toy Store Parent
Finnerty Steeves
Role: Toy Store Parent
John Speredakos
Role: Parent with Girls
Skai Jackson
Role: Kicking Girl
Alex Hall
Role: Skateboard Kid
Eric Redgate
Role: Skateboard Kid
Jojo Gonzalez
Role: FAO Custodian
Tyree Michael Simpson
Role: Cop
Sean Ringgold
Role: Inmate Bubba
Mario D'Leon
Role: Bubba's Inmate Friend
Liz Smith
Role: Party Guest
Tom Colicchio
Role: Party Guest
Michael Musto
Role: Party Guest
Joan Rivers
Role: Party Guest
Olivia Palermo
Role: Party Guest
Julia Enescu
Role: Party Guest
Lauren Waggoner
Role: Party Guest
Alan Cumming
Role: Gutsy Smurf (voice)
Fred Armisen
Role: Brainy Smurf (voice)
George López
Role: Grouchy Smurf (voice)
Kenan Thompson
Role: Greedy Smurf (voice)
Jeff Foxworthy
Role: Handy Smurf (voice)
John Oliver
Role: Vanity Smurf (voice)
Wolfgang Puck
Role: Chef Smurf (voice)
Gary Basaraba
Role: Hefty Smurf (voice)
Paul Reubens
Role: Jokey Smurf (voice)
B.J. Novak
Role: Baker Smurf (voice)
Tom Kane
Role: Narrator Smurf (voice)
John Kassir
Role: Crazy Smurf (Voice)
Joel McCrary
Role: Farmer Smurf (voice)
Mary McGloin
Role: Mother of Girl in Store (uncredited)
Karen Izaguirre
Role: Party Guest
Gérard Hernandez
Role: (voice) (uncredited)
Cœur de Pirate
Role: (voice) (uncredited)
Lorànt Deutsch
Role: (voice) (uncredited)
