Tobey Maguire
Role: Spider-Man / Peter Parker
Willem Dafoe
Role: Green Goblin / Norman Osborn
Kirsten Dunst
Role: Mary Jane Watson
James Franco
Role: Harry Osborn
Cliff Robertson
Role: Ben Parker
Rosemary Harris
Role: May Parker
J.K. Simmons
Role: J. Jonah Jameson
Joe Manganiello
Role: Flash Thompson
Gerry Becker
Role: Maximilian Fargas
Bill Nunn
Role: Joseph 'Robbie' Robertson
Jack Betts
Role: Henry Balkan
Stanley Anderson
Role: General Slocum
Ron Perkins
Role: Dr. Mendel Stromm
Michael Papajohn
Role: Carjacker
Bruce Campbell
Role: Ring Announcer
Elizabeth Banks
Role: Miss Brant
John Paxton
Role: Houseman
Tim DeZarn
Role: Philip Watson
Taylor Gilbert
Role: Madeline Watson
Randy Poffo
Role: Bone Saw McGraw
Larry Joshua
Role: Wrestling Promoter
Timothy Patrick Quill
Role: Wrestling Arena Guard
Lisa Danielle
Role: Bone-ette
Natalie T. Yeo
Role: Bone-ette
Erica D. Porter
Role: Bone-ette
Kristen Davidson
Role: Bone-ette
Jason Padgett
Role: Flash's Crony
Shan Omar Huey
Role: Teacher
Sally Levi
Role: Girl on Bus
Jim Ward
Role: Project Coordinator
David Holcomb
Role: Test Pilot
Octavia Spencer
Role: Check-In Girl
Brad Grunberg
Role: Heckler
Shane Habberstad
Role: Little Billy
Deborah Wakeham
Role: Billy's Mom
Rachael Bruce
Role: Times Square Child
Mackenzie Bryce
Role: Times Square Child
Julia Barrie
Role: Times Square Child
Myk Watford
Role: Cop at Fire
Bill Calvert
Role: Fireman
Sylva Kelegian
Role: Mother at Fire
Kristen Marie Holly
Role: Young Lady at Fire
Scott Spiegel
Role: Marine Cop
Matt Smith
Role: Cop at Carjacking
Sara Ramirez
Role: Cop at Carjacking
Lucy Lawless
Role: Punk Rock Girl
Jayce Bartok
Role: Subway Guitarist
Maribel González
Role: Lady Dogwalker
Amy Bouril
Role: Office Lady
Joseph D'Onofrio
Role: Opinionated Cop
Jim Norton
Role: Surly Truck Driver
Corey Mendell Parker
Role: Chaperone in Tram
Ashley Edner
Role: Girl in Tram
William Joseph Firth
Role: Boy in Tram
Alex Black
Role: Boy in Tram
Laura Gray
Role: Tram Group Mother
Joe Virzi
Role: New Yorker on Bridge
Michael Edward Thomas
Role: New Yorker on Bridge
Jeanie Fox
Role: New Yorker on Bridge
Robert Kerman
Role: Tugboat Captain
Stan Lee
Role: Man in Fair (uncredited)
Una Damon
Role: Lab Tour Guide (uncredited)
Rick Avery
Role: Cop (uncredited)
Peter Aylward
Role: Colonel (uncredited)
Jillian Clare
Role: Crying Girl in Tram (uncredited)
Chris Coppola
Role: Kyle (uncredited)
Jesse Heiman
Role: Spectator at School Fight (uncredited)
Leroy Patterson
Role: World Unity Festival Attendant (uncredited)
Benny Urquidez
Role: Mugger (uncredited)
Scott L. Schwartz
Role: Screaming Wrestler (uncredited)
Jophery C. Brown
Role: Chef (uncredited)
Brian J. Williams
Role: Young Thug #2 (uncredited)
Mark De Alessandro
Role: Cop (uncredited)
Tia Dionne Hodge
Role: Uptown Woman (uncredited)
Loren Janes
Role: Board of Directors Member (uncredited)
Andray Johnson
Role: Balkan's Aide (uncredited)
Martin Pfefferkorn
Role: Thug on 8x10 (uncredited)
Tammi Sutton
Role: Street Vendor (uncredited)
Lindsay Thompson
Role: Mary Jane's Friend (uncredited)
Sean Valla
Role: Boat Light Man (uncredited)
Pete Macnamara
Role: Pentagon Officer (uncredited)
Al Goto
Role: Cop (uncredited)
Joni Avery
Role: Cop (uncredited)
Sam Raimi
Role: Popcorn Thrower (uncredited)
Craig 'Radio Man' Castaldo
Role: Man with Bike (uncredited)
