Tobey Maguire
Role: Spider-Man / Peter Parker
Kirsten Dunst
Role: Mary Jane Watson
James Franco
Role: Harry Osborn
Alfred Molina
Role: Doc Ock / Otto Octavius
Rosemary Harris
Role: May Parker
J.K. Simmons
Role: J. Jonah Jameson
Donna Murphy
Role: Rosalie Octavius
Daniel Gillies
Role: John Jameson
Dylan Baker
Role: Dr. Curt Connors
Bill Nunn
Role: Joseph 'Robbie' Robertson
Vanessa Ferlito
Role: Louise
Aasif Mandvi
Role: Mr. Aziz
Willem Dafoe
Role: Green Goblin / Norman Osborn
Cliff Robertson
Role: Ben Parker
Elizabeth Banks
Role: Miss Brant
Bruce Campbell
Role: Snooty Usher
Gregg Edelman
Role: Dr. Davis
Ilya Baskin
Role: Mr. Ditkovitch
Mageina Tovah
Role: Ursula
Daniel Dae Kim
Role: Raymond
Hal Sparks
Role: Elevator Passenger
Joel McHale
Role: Mr. Jacks
Stan Lee
Role: Man Dodging Debris
Kelly Connell
Role: Dr. Isaacs
Brent Briscoe
Role: Garbage Man
Emily Deschanel
Role: Receptionist
Jason Fiore-Ortiz
Role: Henry Jackson
Scott Spiegel
Role: Man on Balcony
Andy Bale
Role: OsCorp Executive
Christine Estabrook
Role: Mrs. Jameson
Molly Cheek
Role: Society Woman
John Paxton
Role: Houseman
Joy Bryant
Role: Woman at Web
Joanne Baron
Role: Skeptical Scientist
Peter McRobbie
Role: OsCorp Representative
Timothy Jerome
Role: Injured Scientist
Taylor Gilbert
Role: Mrs. Watson
Peter Vouras
Role: Stage Manager
Donnell Rawlings
Role: Pizza "Heist" Witness
Zachry Rogers
Role: Boy saved by Spider-Man
Ella Rogers
Role: Girl saved by Spider-Man
Louis Lombardi
Role: Poker Player
Marc John Jefferies
Role: Amazed Kid
Roshon Fegan
Role: Amazed Kid
Brendan Patrick Connor
Role: Theater Traffic Cop
Reed Diamond
Role: 'Algernon'
Elyse Dinh
Role: Violinist
Tim Storms
Role: Chainsaw Doctor
Susie Park
Role: Clawing Nurse
Patricia M. Peters
Role: Screaming Nurse
Michael Edward Thomas
Role: Man at Fire
Anne Betancourt
Role: Woman at Fire
Venus Lam
Role: Child in Burning Building
Bill E. Rogers
Role: Fireman
Tom Carey
Role: Train Conductor
Jopaul Van Epp
Role: Boy with Mask
Weston Epp
Role: Boy with Mask
Peter Allas
Role: Train Passenger
Brianna Brown
Role: Train Passenger
Bill Calvert
Role: Train Passenger
Tony Campisi
Role: Train Passenger
Joey Diaz
Role: Train Passenger
Chloe Dykstra
Role: Train Passenger
Simone Gordon
Role: Train Passenger
Dan Hicks
Role: Train Passenger
Julia Max
Role: Train Passenger
Savannah Pope
Role: Train Passenger
Timothy Patrick Quill
Role: Train Passenger
Jill Sayre
Role: Train Passenger
Rickey G. Williams
Role: Train Passenger
Michael Arthur
Role: NYPD Officer (uncredited)
Frank Bonsangue
Role: Pizza Man (uncredited)
Cindy Cheung
Role: Chinese Daughter (uncredited)
Phil LaMarr
Role: Train Passenger (uncredited)
Andre M. Johnson
Role: Fireman 2 (uncredited)
Peter Cincotti
Role: Piano Player in Planetarium (uncredited)
Troy Metcalf
Role: Blue Collar Guy (uncredited)
Scott Ross
Role: Pedestrian (uncredited)
Bonnie Somerville
Role: Screaming Woman (uncredited)
Wesley Volcy
Role: Columbia University Student (uncredited)
Lou Volpe
Role: Man at Web (uncredited)
Garrett Warren
Role: Bearded Doctor (uncredited)
Joseph M. Caracciolo
Role: Priest at Mary Jane's Wedding (uncredited)
David Boston
Role: Pedestrian (uncredited)
Sho Brown
Role: Passenger (uncredited)
Sal Ardisi
Role: Parent (uncredited)
Edward Johnson
Role: Planetarium (uncredited)
Grant Curtis
Role: Hot Dog Vendor (uncredited)
Vince Cupone
Role: Victim (uncredited)
William E. Corcoran
Role: Stock Broker (uncredited)
Mohammed Hassan
Role: Middle Eastern Taxi Driver (uncredited)
Rachel Lehrer
Role: Hot Girl (uncredited)
Gene LeBell
Role: Train Passenger (uncredited)
Lorelei Llee
Role: Bank Employee (uncredited)
Joseph Nelson
Role: Extra (uncredited)
Claudia Katz Minnick
Role: Robbie's Assistant (uncredited)
Ronn Ozuk
Role: Cop (uncredited)
Denney Pierce
Role: Train Passenger (uncredited)
Carla Rhodes
Role: Phone Booth Girl (uncredited)
Randy Reinholz
Role: Train Passenger (uncredited)
Rachelle Roderick
Role: Jane, Engineer (uncredited)
Angel Katherine Taormina
Role: Female Onlooker on Street (uncredited)
Douglas Swander
Role: Train Passenger (uncredited)
Jimmy Star
Role: Reporter (uncredited)
Jack Wetherall
Role: Train Passenger (uncredited)
Ken Wharton
Role: Uptight Businessman (uncredited)
Henry Truong
Role: Doc Ock Lab Assistant #2 (uncredited)
Al Collado
Role: Cab Driver (uncredited)
Lee Cogburn
Role: Train Passenger (uncredited)
Sam Raimi
Role: University Student with Bag (uncredited)
John Cameron
Role: Man Buying 'Spider-Man No More' Newspaper (uncredited)
