Tobey Maguire
Role: Spider-Man / Peter Parker
Kirsten Dunst
Role: Mary Jane Watson
James Franco
Role: New Goblin / Harry Osborn
Thomas Haden Church
Role: Sandman / Flint Marko
Topher Grace
Role: Venom / Eddie Brock
Bryce Dallas Howard
Role: Gwen Stacy
Rosemary Harris
Role: May Parker
J.K. Simmons
Role: J. Jonah Jameson
James Cromwell
Role: Captain Stacy
Dylan Baker
Role: Dr. Curt Connors
Theresa Russell
Role: Emma Marko
Bill Nunn
Role: Joseph 'Robbie' Robertson
Bruce Campbell
Role: Maître D'
Elizabeth Banks
Role: Miss Brant
Perla Haney-Jardine
Role: Penny Marko
Willem Dafoe
Role: Green Goblin / Norman Osborn
Cliff Robertson
Role: Ben Parker
Ilya Baskin
Role: Mr. Ditkovitch
Mageina Tovah
Role: Ursula
John Paxton
Role: Houseman
Becky Ann Baker
Role: Mrs. Stacy
Stan Lee
Role: Man in Times Square
Michael Papajohn
Role: Dennis Carradine / Carjacker
Joe Manganiello
Role: Flash Thompson
Hal Fishman
Role: Anchorman
Lucy Gordon
Role: Jennifer Dugan
Steve Valentine
Role: Photographer
Tim Maculan
Role: Play Director
Marc Vann
Role: Play Producer
Joe Bays
Role: Jazz Club Manager
Gregg Daniel
Role: Precinct Detective
Rogelio T. Ramos
Role: Emergency Room Doctor
Timothy Patrick Quill
Role: Crane Operator
Menachem Mendel Boymelgreen
Role: Kid in Times Square
Nasir Stewart
Role: Kid in Times Square
Austin Hendrickson
Role: Kid in Times Square
Taylor Hemhauser
Role: Kid in Times Square
Kathryn Bryding
Role: Woman Outside Theater
Joe Virzi
Role: Police Detective
Bill E. Rogers
Role: New Jersey State Policeman
Michael Alexander
Role: New Jersey State Policeman
April Parker Jones
Role: Test Site Technician
Edward Padilla
Role: Test Site Technician
Robert Curtis Brown
Role: Test Site Technician
Paul Terrell Clayton
Role: Test Site Technician
Carolyn Neff
Role: Test Site Technician
Christina Cindrich
Role: Test Site Technician
Sonya Maddox
Role: ICU Nurse
Andre B. Blake
Role: Crane Disaster Radio Policeman
Derrick 'Phoenix' Thomas
Role: Cop at Crane Disaster
Jessi Collins
Role: Mary Jane's Replacement
Michael McLaughlin
Role: Boy at Key to the City Ceremony
Anne Gartlan
Role: Councilwoman
Emilio Rivera
Role: Policeman at Sand Truck
Keith Woulard
Role: Policeman at Sand Truck
Reynaldo Gallegos
Role: Armored Car Driver
Jim Coope
Role: Newstand Patron
Dean Edwards
Role: Newsstand Patron
Margaret Laney
Role: Newsstand Patron
Toni Wynne
Role: Congratulatory Woman at Daily Bugle
Aimee Miles
Role: Coffee Shop Waitress
Tanya Bond
Role: Jazz Club Waitress
Mark Kubr
Role: Jazz Club Bouncer
Emma Raimi
Role: Girl With Camera
Lorne Raimi
Role: Boy at the Final Battle
Henry Raimi
Role: Boy at the Final Battle
Samantha Ressler
Role: Girl at the Final Battle
Alan Cohn
Role: Jazz Club Musician
Dan Callahan
Role: Jazz Club Musician
Daniel Cummings
Role: Jazz Club Musician
Ron King
Role: Jazz Club Musician
Carol Chaikin
Role: Jazz Club Musician
Vance Hammond
Role: Jazz Club Musician
Frank Anello
Role: NYPD Officer (uncredited)
Anya Avaeva
Role: Model (uncredited)
David Backus
Role: Bucket Boy (uncredited)
Tony Besson
Role: Photoshoot Client (uncredited)
Michael Ciesla
Role: Photographer (uncredited)
Irina Costa
Role: Jazz Club Waitress (uncredited)
John Crann
Role: Theater Patron (uncredited)
Crystal Marie Denha
Role: Jazz Club Girl (uncredited)
Amy V. Dewhurst
Role: Columbia Grad Student (uncredited)
Keith Fausnaught
Role: Pedestrian (uncredited)
Logan Fry
Role: Automobile Driver (uncredited)
Tony Galtieri
Role: News Spectator (uncredited)
Brian Hopson
Role: News Reporter (uncredited)
Andrew James Jones
Role: Jazz Club Bouncer (uncredited)
Natalie Jones
Role: Girl at Key Ceremony (uncredited)
Christopher Jude
Role: Student (uncredited)
Brittany Krall
Role: ER Nurse (uncredited)
Pierangeli Llinas
Role: Woman in Court (uncredited)
Bernadette Lords
Role: British Publicist (uncredited)
Natalie McNeil
Role: Girl Screaming in Camaro (uncredited)
Martha Millan
Role: Oscorp Receptionist (uncredited)
Michele-Nanette Miller
Role: Girl in Times Square (uncredited)
Claudia Katz Minnick
Role: Robbie's Assistant (uncredited)
Jen Oda
Role: Beautiful Girl (uncredited)
Anjelia Pelay
Role: Beautiful Woman (uncredited)
Nick Poltoranin
Role: Police Officer (uncredited)
Vanessa Reseland
Role: Beautiful Woman (uncredited)
La Rivers
Role: Beautiful Woman (uncredited)
Bria Roberts
Role: Businesswoman (uncredited)
Vanessa Ross
Role: Sandman Victim (uncredited)
Brenna Roth
Role: Bad Girl (uncredited)
Shade Rupe
Role: City Hall Cheerer (uncredited)
Abbey Skinner
Role: Café Girl (uncredited)
Daniel Shafer
Role: Jazz Club Guest (uncredited)
Kristin Somo
Role: Jazz Club Patron (uncredited)
Jennifer Sparks
Role: Jazz Club Waitress (uncredited)
Christopher Stadulis
Role: NY Firefighter (uncredited)
Aija Terauda
Role: Model (uncredited)
Evelyn Vaccaro
Role: Beautiful Woman (uncredited)
Nick Vlassopoulos
Role: Bar Patron #5 (uncredited)
Sincerely A. Ward
Role: Model (uncredited)
Jennifer Weston
Role: ER Nurse (uncredited)
Ray Wineteer
Role: Spectator (uncredited)
Emily Eckes
Role: Beautiful Woman (uncredited)
Craig 'Radio Man' Castaldo
Role: Radioman (uncredited)
Laura McDavid
Role: Journalist (uncredited)
